Which of the following best explains why sickle-cell anaemia causes anaemia in affected individuals?

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Question

Which of the following best explains why sickle-cell anaemia causes anaemia in affected individuals?

Accepted Answer

Sickle-shaped cells have a shorter lifespan and are destroyed faster than they are replaced — Sickle-shaped red blood cells are fragile and are destroyed by the spleen much faster than normal red blood cells. Because the body cannot replace them quickly enough, the total red blood cell count falls, resulting in anaemia. Normal red blood cells live about 120 days, whereas sickle cells survive only 10–20 days.

Answer

Sickle cells produce excess haemoglobin, disrupting iron balance

Answer

Sickle cells multiply too rapidly, reducing plasma volume

Answer

Sickle cells block the bone marrow, preventing red blood cell production

Answer

Sickle-shaped cells have a shorter lifespan and are destroyed faster than they are replaced

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