Sickle cell disease is common in parts of the Caribbean where malaria was historically present. Which statement correctly describes the inheritance of sickle cell disease?

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Question

Sickle cell disease is common in parts of the Caribbean where malaria was historically present. Which statement correctly describes the inheritance of sickle cell disease?

Accepted Answer

It is caused by a recessive allele on an autosome — Award 1 mark for identifying sickle cell disease as autosomal recessive. A is incorrect — sickle cell is not X-linked and is recessive, not dominant. C is incorrect — the allele is recessive, not dominant. D is incorrect — the gene is located on chromosome 11, an autosome, not the Y chromosome.

Answer

It is caused by a recessive allele on the Y chromosome

Answer

It is caused by a dominant allele on an autosome

Answer

It is caused by a recessive allele on an autosome

Answer

It is caused by a dominant allele on the X chromosome

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